Pentobarbital will decrease the level or effect of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of quinine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of alosetron by affecting hepatic/intestinal enzyme C... https://bookmarkstumble.com/story22221592/the-ultimate-guide-to-pentobarbital-de-sodium