Pentobarbital will lessen the level or impact of zonisamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified. pentobarbital will lessen the level or effect of bosentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar. This drug may raise the metabolism of estradiol when administered concurrently; patients on... https://jackh900slb1.hyperionwiki.com/user