Gastrointestinal (GI): NSAIDs that block COX-1 exercise have correlations with GI issues due to the inhibition on the synthesis of gastroprotective agents including PGE2 along with other prostaglandins. This inhibition contributes to lowered mucin generation by gastric epithelial cells, less bicarbonate secretion, and less epithelial mobile turnover, among other actions. https://jeremyz468ttr8.wikinstructions.com/user